The funniest thing about this book is the dedication page. "This book is for doctors everywhere." Ha! Roald Dahl was such a cheeky devil. George is stuck at home alone with his mean, scary, and very demanding grandma. He's supposed to give her medicine at eleven o'clock. Instead of giving her the usual medicine, he concocts a replacement batch, hoping it will improve Grandma's disposition. To create his "Marvelous Medicine," George throws in absolutely everything he can find around the house. Shaving soap, hair remover, dandruff cure, laundry soap, flea powder, shoe polish, black pepper, horseradish sauce, animal pills, curry powder, deodorant spray, brown paint...EVERYTHING. The medicine doesn't make Grandma any nicer, but it DOES have a remarkable effect on her, and on every creature they give it to. George's dad wants him to make another batch, but there's a problem. George didn't write down the recipe. So every new batch he tries is missing something, and has a different effect when they test it on the farm animals. Batch Number Four solves the Grandma problem permanently. The way it does so makes the book's dedication especially funny.